The inventor and most prolific practitioner of vocalese was Eddie Jefferson, whose rendition of Coleman Hawkins's "Body and Soul" became a hit on its own. Pioneers of vocalese include King Pleasure and Babs Gonzales, Jefferson's former dance partner. The best-known practitioners are probably Lambert, Hendricks and Ross, which was made up of Jon Hendricks, Dave Lambert and Annie Ross. Ross's 1952 lyrics for the song "Twisted", a blues improvisation by saxophonist Wardell Gray, are considered a classic of the genre. Other performers known for vocalese include Bob Dorough, Giacomo Gates
, Kurt Elling, Al Jarreau, and The Manhattan Transfer, with their Grammy-winning version of Weather Report's "Birdland" set to lyrics by Jon Hendricks.
Some performers, notably Slim Gaillard, Harry Gibson, Cab Calloway and Leo Watson, combine vocalese improvisations with scat singing.
Most vocalese lyrics are entirely syllabic, as opposed to melismatic. This may lead to the use of many words sung quickly in a given phrase, especially in the case of bebop.