vitamin K

Vitamin-K-epoxide reductase (warfarin-insensitive)

In enzymology, a vitamin-K-epoxide reductase (warfarin-insensitive) is an enzyme that catalyzes the chemical reaction

3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol rightleftharpoons 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

Thus, the two substrates of this enzyme are 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone and oxidized dithiothreitol, whereas its two products are 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone and 1,4-dithiothreitol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a disulfide as acceptor. The systematic name of this enzyme class is 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithi othreitol oxidoreductase.


  • Mukharji I, Silverman RB "Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone". Proc. Natl. Acad. Sci. U. S. A. 82 2713–7.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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