Huston became the third generation of her family to win an Oscar for her performance in 1985's Prizzi's Honor, joining her director father, John, and actor grandfather, Walter. She later was nominated in 1990 and 1991 for her acting in Enemies, a Love Story and The Grifters respectively. Among her roles, she starred as Morticia Addams in The Addams Family (1991) and Addams Family Values (1993), receiving Golden Globe nominations for both.
Huston would again retreat to familiar roots, taking on small roles in films in the early 1980s: one in which she would star alongside Jack Nicholson and Jessica Lange in Bob Rafelson's The Postman Always Rings Twice (1981), and Frances (1982), which would also star Jessica Lange. Huston would also appear in television series, Laverne & Shirley and Faerie Tale Theatre.
After taking on several small but prominent roles in both film and in television, Huston landed her big role, winning an Academy Award for Best Supporting Actress for her role as Maerose Prizzi in Prizzi's Honor (1985), a film directed by her father, John Huston and starring opposite Jack Nicholson and Kathleen Turner. With Anjelica's win, she became the first third-generation Academy Award winner, having been preceded by her father and by her grandfather, actor Walter Huston.
Huston was nominated for another Academy Award for Best Supporting Actress for her role as Tamara Broder in Enemies, a Love Story (1989) and another for Best Actress in a Leading Role for her role as Lily Dillon in The Grifters (1990). She received three Saturn Award nominations for one of her most memorable roles, The Grand High Witch in The Witches (1990). Later she received nominations for her role as Morticia Addams in Addams Family Values (1993) and for her role as Baroness Rodmilla de Ghent in Ever After (1998).
Over the years, Huston received five Emmy Award nominations for her television work. She won a Golden Globe Award for Supporting Actress in a TV Program for Iron Jawed Angels (2004). It was her first win after eight nominations. She appeared in several films by Wes Anderson, starting with The Royal Tenenbaums (2001) and The Life Aquatic With Steve Zissou (2004), as well as The Darjeeling Limited (2007).
In January 2008, Huston joined the cast of Medium at the start of its fourth season for a six-episode story arc. Her character is a missing persons investigator who employs the psychic abilities of Allison DuBois. Her performance earned her a sixth Emmy nomination.
|1967||Casino Royale||Agent Mimi's Hands||uncredited|
|A Walk with Love and Death||Claudia|
|1975||One Flew Over the Cuckoo's Nest||Woman in Crowd on Pier||uncredited|
|1976||Swashbuckler||Woman of Dark Visage|
|The Last Tycoon||Edna|
|1981||The Postman Always Rings Twice||Madge|
|1982||Rose for Emily||Miss Emily Grierson|
|The Comic Book Kids||The Princess|
|Frances||An extra|| Huston was a mental patient rocking back and forth on a bed|
under a blanket. View DVD, Frances (2001), chapter 23.
|1984||This is Spinal Tap||Polly Deutsch|
|The Ice Pirates||Maida|
|1985||Prizzi's Honor||Maerose Prizzi||Academy Award for Best Supporting Actress; Nominated - BAFTA Award; Nominated - Golden Globe|
|1986||Captain EO||The Supreme Leader|
|Good to Go|
|1987||Gardens of Stone||Samantha Davis|
|The Dead||Gretta Conroy||Independent Spirit Award|
|1988||Mr. North||Persis Bosworth-Tennyson|
|A Handful of Dust||Mrs. Rattery|
|1989||Crimes and Misdemeanors||Dolores Paley||Nominated - BAFTA Award|
|Enemies, a Love Story||Tamara Broder||Nominated - Academy Award for Best Supporting Actress|
|1990||The Witches||Eve Ernst/ The Grand High Witch|
|The Grifters||Lilly Dillon||Independent Spirit Award; Nominated - Golden Globe;|
Nominated - Academy Award for Best Actress;
|1991||The Addams Family||Morticia Addams||Nominated - Golden Globe|
|1993||Manhattan Murder Mystery||Marcia Fox||Nominated - BAFTA Award|
|Addams Family Values||Morticia Addams||Nominated - Golden Globe|
|1995||The Perez Family||Carmela Perez|
|The Crossing Guard||Mary||Nominated - Golden Globe|
|1998||Ever After||Baroness Rodmilla de Ghent|
|Buffalo '66||Billy Brown's Mother|
|1999||Agnes Browne||Agnes Browne|
|The Golden Bowl||Fanny Assingham|
|2001||The Royal Tenenbaums||Etheline Tenenbaum|
|The Mists of Avalon||Viviane, Lady of Lake|
|2002||Blood Work||Dr. Bonnie Fox||Rapunzel||Dame Gothel||voice: English version|
|2003||Daddy Day Care||Ms. Harridan|
|Kaena: La prophétie||Queen of the Selenites||voice: English version|
|2004||The Life Aquatic with Steve Zissou||Eleanor Zissou|
|Iron Jawed Angels||Carrie Chapman Catt|
|2006||Art School Confidential||Art History Teacher|
|These Foolish Things||Lottie Osgood|
|2007||Seraphim Falls||Madame Louise Fair|
|The Darjeeling Limited||Patricia Whitman|
|Martian Child||Crass Publisher|
|Tinker Bell||Queen Clarion||awaiting release|
|Spirit of the Forest||Mrs. D'Abondo||post-production|
|2009||When in Rome||Guggenheim Curator||post-production|
|The Fantastic Mr. Fox||TBA||post-production|