Velpeau was a skilled surgeon and renowned for his knowledge of surgical anatomy, and he published over 340 titles on surgery, embryology, anatomy, obstetrics, et al. In 1830 he published an important book on obstetrics, titled Traité elementaire de l’art des accouchements. Also, in 1827 Velpeau was the first physician to describe acute myeloid leukemia.
The eponymous Velpeau bandage that is used for arm support is named after him. There are several other eponyms regarding Velpeau. However, they are now primarily used for historical purposes only; these include: Velpeau hernia for the femoral hernia, Velpeau's disease for hidradenitis suppurativa, Velpeau's canal for the inguinal canal and Velpeau's fossa which is the ischiorectal fossa.
Despite being one of the top surgeons in his time, Velpeau believed that pain-free surgery was a fantasy, and that surgery and pain were inseparable. With the advent of anaesthetics such as ether and chloroform in the 1840's, Velpeau was amazed, saying "On the subject of ether, that it is a wonderful and terrible agent, I will say of chloroform, that it is still more wonderful and more terrible"