• Venture capital, financing of growing businesses
• Vietcong A communist army during the Vietnam War
• Vice-Chancellor, the chief executive of a university
• Victoria Cross, the highest British and Commonwealth award for valour in the face of the enemy
• Video card
• Vigilance committee
• Vince Carter, a National Basketball Association player with the New Jersey Nets
• Vinyl chloride, a chemical used in the production of PVC
• Violoncello (usually abbreviated to cello), a bowed string instrument
• Virtual Console, a Nintendo video game download service for the Wii game console
• Visual Composer, a modeling tool
• Visual cryptography
• Vitamin C, an essential nutrient
• Voluntary controlled school
• In linguistics, a vowel-consonant syllable pattern
• Versus Christus, the Antichrist

VC may also refer to:

In computing and telecommunications:

• Vapnik-Chervonenkis theory, a computational learning theory
• Virtual circuit, a telecommunications arrangement
• Virtual console (computer user-interface), a combination of a computer display and keyboard
• Virtual container, part of the SDH/SONET architecture
• Visual C++, an integrated development environment product engineered by Microsoft for C and C++ programing languages
• Volkov Commander, a computer program for managing files

In entertainment:

• Vanessa Carlton, an American pop singer
• Vice City, a fictional city in the computer game series Grand Theft Auto
• Tien Len, aka Vietnamese Cards or VC, a traditional card game originating in Vietnam
• Violoncello, under the musical score abbreviation
• Visual Communications (VC), a non-profit Asian Pacific American media arts organization in Los Angeles
• Voyage Century, an MMORPG pirate game based on sailing in the trade winds era

In geography:

• the ISO country code for Saint Vincent and the Grenadines, a state in the Caribbean
• Vatican City, a sovereign city-state within Rome, Italy
• Watsonian vice-counties, subdivisions of Great Britain or Ireland

In transport:

• Holden VC Commodore, an automobile introduced by Holden in 1980
• Ocean Airlines, IATA airline designator
• V_C speed, cruising speed in aircraft design
• Vehicular cycling, driving a bicycle on public roads
• Virginia Central Railroad, a U.S. railroad (AAR reporting mark)
• Voyageur Airways, IATA airline designator