Harvard researchers report that supplementation in rats with a combination of uridine and EPA/DHA omega-3 fatty acids has antidepressant activity equivalent to that of commonly prescribed antidepressant medications, such as Prozac and other SSRIs.
Sugarcane extract is rich in nucleosides, especially uridine. Tomatoes also (about 500-1000 mg. of uridine per kilogram of dry matter).. Brewer's yeast also contains a good amount of uridine, as yeast is high in RNA, which after digestion is broken down into uridine monophosphate. About 3 percent of yeast (dry weight) results in digestion uridine products. This assumes the usual 9% RNA content found in Brewer's yeast. However, not all commercial yeast products may contain this level of RNA. Alternatively, drinking beer also results in increased plasma uridine . The ingestion of one liter of beer results in increased plasma uridine at a level that is comparable to those reached after ingestion of CDP-choline (citicoline) (as in , the increase is measured as a percent change relative to baseline plasma uridine).