Companies

• United Parcel Service, an international shipping company

Organizations

• Underground Press Syndicate
• Union-Philanthropic Society of Hampden-Sydney College
• Union Philosophical Society
• Union Progressiste Sénégalaise, the former name of the Socialist Party of Senegal
• Universal Pantheist Society
• University of Puget Sound, a university in Tacoma, Washington
• University Philosophical Society of Trinity College, Dublin

Science, technology, and medicine

• Ubiquitin proteasome system
• Ultra-violet photoelectron spectroscopy
• Ultra-violet photoemission spectroscopy
• Uninterruptible power supply
• Universal Polar Stereographic coordinate system
• UNIX Product Support
• Ups (debugger)
• Unexplained physical symptoms, frustrating but inevitable facts of life that often present challenges not just to mental health care providers, but also to primary care physicians

Other

• USS Puget Sound