The alpha 3 protein constituent of type-IV collagen is thought to be the antigen implicated in Goodpasture's syndrome, wherein the immune system attacks the basement membranes of the glomeruli and the alveoli.
There are six human genes associated with it:
Mutations to the genes coding for type-IV collagen lead to Alport syndrome.
Spondyloepiphyseal dysplasia congenita associated with conductive hearing loss.(Brief Article)(Statistical Data Included)
Mar 01, 2000; Abstract Spondyloepiphyseal dysplasia is a disorder characterized by abnormalities of growth. Previous studies of this disorder...