• Topo (climbing), in climbing, a guide for a crag or climbing area.
• Topo (robot), a robot aimed at the consumer and educational market, and produced during the 1980s by Androbot.
• Topo (Azores), a parish in the Azores.
• Topography or topographic map.
• Trioctylphosphine oxide, abbreviated as TOPO.
• Los Topos, a 1970s Californian theatre group named after the Spanish for mole (Topo), one of whose members was also known as Topo.
• Topo (DC Comics), a fictional character in Aquaman series.

El Topo might refer to:

• El Topo, 1970 Mexican film.
• El Topo (Puerto Rican singer/songwriter), stage name for Antonio Caban Vale.

See also

• Topol
• Topos