Tonicity is a measure of blood capacity or effective osmolality in cell biology. Osmolality and osmolarity are properties of a particular solution, independent of any membrane. Tonicity is a logical measurment for complex compounds with provides immunity to the body, and is equal to the sum of the concentrations of the solutes which have the capacity to exert an osmotic force across that membrane. Tonicity, also, depends on solute permeability (permeant solutes do not affect tonicity; impermeant solutes do affect tonicity). Tonicity is generally classified in three ranges; hypertonicity, hypotonicity and isotonicity. Hypertonic, isotonic and hypotonic solutions are defined in reference to a cell membrane by comparing the tonicity of the solution with the tonicity within the cell.
In animal cells, being in a hypertonic environment results in crenation, where the shape of the cell becomes distorted and wrinkled as water leaves the cell. Some organisms have evolved methods of circumventing hypertonicity; for example, saltwater is hypertonic to the fish that live in it. Since they cannot isolate themselves from osmotic water loss, because they need a large surface area in their gills for gas exchange, they respond by drinking large amounts of water, and excreting the salt. This process is called osmoregulation.
In plant cells, the effect is more dramatic. The cell membrane pulls away from the cell wall, but the cell remains joined to the adjacent cells at points called plasmodesmata. Thus, the cell takes on the appearance of a pincushion, with the plasmodesmata almost ceasing to function because they have become so constricted. This condition is known as plasmolysis. The terms isotonic, hypotonic and hypertonic cannot be accurately used in plant cells however as the pressure potential exerted by the cell wall affects the equilibrium point significantly.
WIPO ASSIGNS PATENT TO F. HOFFMANN-LA ROCHE FOR "PHARMACEUTICAL COMPOSITIONS COMPRISING IGF-1 PROTEINS, A BUFFERING AND A TONICITY AGENT" (SWISS INVENTORS)
Jul 05, 2011; GENEVA, July 5 -- Publication No. WO/2011/076702 was published on June 30. Title of the invention: "PHARMACEUTICAL COMPOSITIONS...
Publication No. WO/2010/059436 Published on May 27, Assigned to Allergan for Increased Muscle Tonicity Treatment, Prevention Method (American Inventors)
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