, abbreviated "ThioTEPA," is an organophosphorus compound
with the formula SP(NC2
. This cancer chemotherapeutic
member of the alkylating agent
group has been in use for since the 1960s. It is an analogue of N,N',N''- triethylenephosphoramide (TEPA
). It is mostly used to treat breast cancer
, ovarian cancer
, and bladder cancer
. It is also used as conditioning for bone marrow transplantation
. Its main toxicity is myelosuppression
This molecule features tetrahedral phosphorus and is structurally akin to phosphate. It is derived from aziridine and thiophosphoryl chloride.
- Sykes M et al. (1953). "Clinical Studies of triethylenephosphoramide compounds with nitrogen mustard-like activity". Cancer 6 142–48.
- Maanen MJ, Smeets CJ, Beijnen JH (2000). "Chemistry, pharmacology and pharmacokinetics of N,N',N" -triethylenethiophosphoramide (ThioTEPA)". Cancer Treat Rev 26 (4): 257–68.