Computing

• Transmission Control Protocol, transport layer protocol (L4) that is one of the core protocols of the Internet protocol suite
• Trusted Computing Platform, a cross-platform hardware-based platform for improved security

Medicine and drugs

• TCP (antiseptic), the brand name of an antiseptic formerly containing Trichlorophenylmethyliodosalicyl, a germicide
• Two Component Plasma, a blood plasma containing a cool thermal component and a population of high energy particles
• Transcutaneous pacing, a temporary means of pacing a patient's heart during a medical emergency
• Tissue Culture Plate, a device for creating cell cultures
• Tenocyclidine, a dissociative anesthetic drug with stimulant and hallucinogenic effects
• Thrombocytopenia, a scarcity of platelets in blood

Chemical compounds

• Trichlorophenol, any organochloride of phenol that contains three covalently bonded chlorine atoms
• Tricresyl phosphate, an organophosphate compound derived from cresol and phosphoric acid

Miscellaneous

• Taba International Airport, near Taba, Egypt
• Thermal conversion process, a process that reduces complex organic materials
• Top Cow Productions, an American company that produces comic books
• Traditional Cultural Property, properties in the United States affiliated with traditional religious and cultural importance
• Trans-Caspian Gas Pipeline, a proposed submarine pipeline between Turkmenistan and Azerbaijan