Tartronate-semialdehyde synthase

2 glyoxylate $rightleftharpoons$ tartronate semialdehyde + CO₂

Hence, this enzyme has one substrate, glyoxylate, and two products, tartronate semialdehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is glyoxylate carboxy-lyase (dimerizing tartronate-semialdehyde-forming). Other names in common use include tartronate semialdehyde carboxylase, glyoxylate carbo-ligase, glyoxylic carbo-ligase, hydroxymalonic semialdehyde carboxylase, tartronic semialdehyde carboxylase, glyoxalate carboligase, and glyoxylate carboxy-lyase (dimerizing). This enzyme participates in glyoxylate and dicarboxylate metabolism. It has 2 cofactors: FAD, and Thiamin diphosphate.

References

• GUPTA NK, VENNESLAND B "GLYOXYLATE CARBOLIGASE OF ESCHERICHIA COLI: A FLAVOPROTEIN". J. Biol. Chem. 239 3787–9.
• BARKULIS SS, KRAKOW G "Conversion of glyoxylate to hydroxypyruvate by extracts of Escherichia coli". Biochim. Biophys. Acta. 21 593–4.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes