Botticelli depicted the life and work of St. Zenobius (337-417), the first bishop of Florence, on four paintings. In the first scene, St Zenobius is shown twice: he rejects the bride that his parents intended him to take in marriage and walks thoughtfully away. The other episodes show the baptism of the young Zenobius and his mother, and on the right his ordination as bishop.
The Histories of St. Zenobius are the last known work of Botticelli. The other three paintings are: