Tachyphylaxis is a medical term describing a rapidly decreasing response to a drug following administration of the initial doses.
LSD-25 and Psilocybin containing mushrooms also demonstrate tachyphylaxis very rapidly. e.g. it may be impossible to 'trip' two days in a row. Some people are able to 'trip' by taking up to 3x the dosage, some users may not be able to negate tachyphylaxis at all until a period of days has gone by.
See Lehne, R. 2007, PHARMACOLOGY FOR NURSING CARE, Saunders/Elsevier, St. Louis, p.79 for more info.
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