Chemical reaction by which unequal amounts of two product isomers are formed. It is normally not possible to synthesize from materials that do not have optical activity (i.e., are not chiral) one stereoisomer of a chiral compound without the other, but use of a chiral auxiliary, such as an enzyme or other catalyst, a solvent, or an intermediate, can force the reaction to produce predominantly or only one isomer. Asymmetric syntheses are often called stereoselective; if one product forms exclusively, it is stereospecific.
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Synthesis of long peptides: native chemical ligation permits the chemoselective ligation of unprotected peptide fragments in aqueous buffer. Ligation occurs between a peptide containing a cysteine at its N-terminus and another peptide modified with a thioester at its C-terminus.(Biochemicals & Kits)
Mar 01, 2008; Introduction The attraction of peptides as therapeutics or research tools comes from their high specificity to targeted sites,...