Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)

In enzymology, a bis(5'-nucleosyl)-tetraphosphatase (symmetrical) is an enzyme that catalyzes the chemical reaction

P1,P4-bis(5'-adenosyl) tetraphosphate + H2O rightleftharpoons 2 ADP

Thus, the two substrates of this enzyme are P1,P4-bis(5'-adenosyl) tetraphosphate and H2O, whereas its product is ADP.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase. Other names in common use include diadenosinetetraphosphatase (symmetrical), dinucleosidetetraphosphatasee (symmetrical), symmetrical diadenosine tetraphosphate hydrolase, adenosine tetraphosphate phosphodiesterase, Ap4A hydrolase, bis(5'-adenosyl) tetraphosphatase, diadenosine tetraphosphate hydrolase, diadenosine polyphosphate hydrolase, diadenosine 5',5-P1,P4-tetraphosphatase, diadenosinetetraphosphatase (symmetrical), 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate, and nucleosidebisphosphohydrolase'''. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .


  • Barnes LD, Culver CA "Isolation and characterization of diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase from Physarum polycephalum". Biochemistry. 21 6123–8.
  • Guranowski A, Jakubowski H, Holler E "Catabolism of diadenosine 5',5"'-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5',5"'-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12". J. Biol. Chem. 258 14784–9.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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