Nasiff was born and lived in Fall River, Massachusetts. He was tall, and weighed . He has said on the show that he is of Lebanese descent.
In 1998, People magazine ran an online poll to determine the most beautiful people in the world, where somebody facetiously entered Nasiff as a write-in candidate. Nasiff won the contest, receiving hundreds of thousands of votes. At the time the online poll was launched, People led voters to believe that it would influence the print magazine's annual listing of "the most beautiful people." People refused to allow online votes to influence the magazine results. The poll was configured so that users could vote multiple times, by deleting a cookie given from the site. Many contestants had scripts written that would allow users to vote repeatedly. Other unlikely candidates in that polls' top 10 included They Might Be Giants keyboardist John Linnell and wrestler Ric Flair.
Nasiff had a brief acting career, with parts ranging from God (Citizen Toxie: The Toxic Avenger Part 4) to Mini-Devil (Bikini Bandits Go To Hell). He also appeared in the independent films Shoeshine Boys and Pint Fiction a dwarf version of Pulp Fiction. Nasiff also appeared in a 2001 episode of the Stern produced Son of the Beach television show (It's a Nude, Nude, Nude, Nude World).
As a popular member of The Wack Pack, Nasiff parlayed his Stern Show exposure into personal appearances all over the country, mostly strip clubs and bachelor parties, where he would, invariably, get drunk and insult party-goers, much to their delight. Nasiff's success waned once Beetlejuice emerged on the scene, which led to a rivalry between the two which culminated in several on-air confrontations. Nasiff and true Stern fans dispute that Beetlejuice was in fact a bigger star causing Hank's success to wane. In fact, Nasiff's popularity rose consistently until and even after his death. The two would berate and threaten each other, entertaining Stern's fans but ultimately never doing more than arguing. Upon learning of Hank's death, Beetlejuice cried profusely, calling him "my friend."
Hank knew a great deal of rock & roll trivia and competed on the Stern Show against producer Gary Dell'Abate. After Hank won one competition on April 25, 2001, the intoxicated, diminutive celebrity announced he was sleepy, laid down on the floor of the radio studio, and slept. Howard announced "Gary, you lost to this mess."
Hank's favorite drink was vodka, which he usually swigged from a soda bottle.
In November 2000, Hank was dispatched in a bunny suit to taunt the magician David Blaine as Blaine was encased in a block of ice for his stunt "Frozen in Time." The same month, Nasiff suffered a seizure while making an appearance for J&B scotch at a bar in Los Angeles.
Hank was found dead in his home in Fall River on September 4, 2001. Stern, cast and crew, The Wack Pack, and fans were in deep mourning until interrupted by the September 11, 2001 attacks; prior to the attacks, a large impromptu memorial had been erected outside WXRK by Stern's and Hank's fans. Medical experts suggest that what led to Nassif's death was a combination of cirrhosis of the liver and internal organ compression due to his stunted height. According to his death certificate, Nasiff died of a seizure disorder. Other significant conditions contributing to his death were alcohol abuse and chondrodystrophy.
Howard Stern revealed on his radio show that a show employee had attempted on multiple occasions to get Hank help for his alcoholism, which was refused..