The multi-subunit enzyme usually has a 3:3 (alpha:beta) stoichiometry with a 2-fold symmetric structure (note that the image above gives the structure of the asymmetric unit, one third of the true biological assembly). An exceptional urease is found in Helicobacter pylori, which combines four of the regular six subunit enzymes in an overall tetrahedral assembly of 24 subunits (). This supra-molecular assembly is thought to confer additional stability for the enzyme in this organism, which functions to produce ammonia in order to neutralise gastric acid. The presence of urease is used in the diagnosis of Helicobacter species.
Urease-positive pathogens include:
Macro- and Supra-molecular Architectures and Materials: 7-11 September 2008, Dusseldorf, Germany.(Where 2B & Y: Announcements of conferences, symposia, workshops, meetings, and other upcoming activities)(Brief article)
May 01, 2008; Novel and functional polymer materials will play a key role in science and technology in the 21st century. As functional...