Bosson starred in the 1970s series Richie Brockelman, Private Eye as Sharon. Other roles include the short-lived series Hooperman and Cop Rock. Some of Bosson's film appearances include her well-known role is in the 1984 hit science fiction film The Last Starfighter.
Bosson has made guest appearances on many shows, ranging from Mannix, Crazy Like a Fox, L.A. Law, Civil Wars, Star Trek: Deep Space Nine (in the season 2 episode "Rivals" as Roana) and Lois & Clark: The New Adventures of Superman.
From 1969 until their divorce in 1997, Bosson was married to writer-producer Steven Bochco, who created several of the series she starred in, including Hill Street Blues, L.A. Law, Murder One, and Cop Rock; they have two children.