Directly observed treatment (DOT) or directly observed therapy is watching the patient take his/her medication to ensure medications are taken in the right combination and for the correct duration. It is used for diseases such as tuberculosis or HIV to assure compliance and avoid drug resistance.
Also, DOTS (directly observed treatment, short-course). The brand name given to the WHO-recommended TB control strategy that combines five components:
DOTS-PLUS is for multi-drug-resistant tuberculosis (MDR-TB).