Sober may refer to:

Biology

• Sobriety, the state of being sober, and not under the influence of alcohol or other drugs

Computers

• Sober, a variety of computer worm
• SOBER (cipher), a family of synchronous stream ciphers
• SOBER-128, a synchronous stream cipher

Entertainment

• Sôber, a Spanish rock band
• "Sober", a song by the progressive rock band Tool from their 1993 album Undertow
• "Sober", a song by Kelly Clarkson
• "Sober", a song from the Muse album Showbiz
• "Sober", a song from the P!nk album Funhouse (2008)

Geography

• Sober, a city in Spain.

Mathematics

• Sober space, a type of sobriety of a topological space in mathematics

People

• Elliott Sober, a philosopher of science