Slow-wave sleep (SWS) is stages three and four of non-rapid eye movement sleep. These two stages are often referred to as deep sleep.
The highest arousal thresholds (e.g. difficulty of awakening, such as by a sound of a particular volume) are observed in stages four and three, respectively. A person will typically feel more groggy when awoken from these stages, and indeed, cognitive tests administered after awakening from stages 3-4 indicate that mental performance is somewhat impaired for periods up to 30 minutes or so, relative to awakenings from other stages. This phenomenon has been called "sleep inertia."
After sleep deprivation there is a sharp rebound of SWS, suggesting there is a "need" for this stage. The major factor determining how much slow-wave sleep is observed in a given sleep period is the duration of preceding wakefulness, likely related to accumulation of sleep-promoting substances in the brain. Some of the few factors known to increase slow-wave sleep in the sleep period that follows them include body heating (as by immersion in a hot tub), high carbohydrate ingestion, and intense prolonged exercise. The latter probably exerts its influence by increasing body temperature.
In addition to these factors, the duration of SWS periods can be increased by ingestion of alcohol, THC, SSRIs, and other drugs. In instances such as these, TST (Total Sleep Time) is often unaffected due to circadian rhythms and/or a person's alarm clock and early morning obligations. This increase of SWS can lead to increased REM latency and a decrease in REM period durations. If the total time spent in REM is decreased long enough and repeatedly over a substantial number of nights a "REM rebound" will occur in response to removal of its inhibitor. An increase in REM is believed to produce symptoms of depression and bipolar disorder in many patients for an amount of time relative to the severity of the previous "REM suppression". It is debatable whether or not this could explain the return in symptoms of depression disorder after removal of SSRI medications.
Certain substances, such as benzodiazepines (e.g. Ativan, Valium, Klonopin) seem to have the reverse effect on the time spent in SWS. Instead of lengthening SWS sleep (as do the substances mentioned above), they are known to shorten the time. While these sedatives can increase sleep duration or shorten the time it takes before sleep-onset occurs, they tend to deprive patients of deep sleep.
Large 75 microvolt (2 - 4 Hz) delta waves predominate the electroencephalogram (EEG). Stage 3 is defined by Rechtschaffen and Kales as the point where delta waves make up 5 or more seconds of a 30 second EEG epoch (generally 8-13 delta waves).
Longer periods of slow-wave sleep occur in the first part of the night, primarily in the first two sleep cycles (roughly 3 hours). Children and young adults will have more total slow-wave sleep in a night than older adults. The elderly may not go into slow-wave sleep at all during many nights of sleep.
The slow wave seen in the cortical EEG is generated through thalamocortical communication through the thalamocortical neurones. In the TC neurones this is generated by the 'slow oscillation' and is dependent on membrane potential bistability, a property of these neurones due to an electrophysiological component known as I t Window. I t Window is due to the overlap underneath activation/inactivation curves if plotted for T-type calcium channels (inward current). If these two curves are multiplied, and another line superimposed on the graph to show a small Ik leak current (outward), then the interplay between these inward (It Window) and outward (small Ik leak), three equilibrium points are seen at -90, -70 and -60mv, -90 and -60 being stable and -70 unstable. This property allows the generation of slow waves due to an oscillation between two stable points. It is important to note that in vitro, mGluR must be activated on these neurones to allow a small Ik Leak, as seen in vivo situations.
EEG in Seizure Prognosis: Association of Slow Wave Activity and Other Factors in Patients with Apparent Misleading Epileptiform Findings
Oct 01, 2004; Key Words Electroencephalography Epilepsy Seizure Sharp Waves Slow Waves Spikes ABSTRACT Our previous study showed that patients...
Slow-Wave Structures Slice VCO Phase Noise; by Combining Mode-Coupling Methods with Slow-Wave Transmission-Line Structures, These VCOs Achieve Both Optimized and Wide Tuning Ranges with Low Phase Noise Comparable to Low-Q Sources
May 01, 2011; Byline: ULRICH L. ROHDE Chairman Synergy Microwave Corp., 201 McLean Blvd., Paterson, NJ 07504; (973) 881-8800,...