Sertoli-Leydig cell tumour
, also known as arrhenoblastoma
, is a member of the sex cord-stromal tumour
group of ovarian
and testicular cancers
. The tumour is rare, comprising less than 1% of ovarian tumours,. While the tumour can occur at any age, it occurs most often in young adults.
The tumour is subdivided into many different subtypes. The most typical is composed of tubules
lined by Sertoli cells
and interstitial clusters of Leydig cells
Due to excess testosterone
secreted by the tumour, one-third of female
patients present with a recent history of progressive masculinization
. Masculinization is preceded by anovulation
. Additional signs include acne
, voice deepening, clitoromegaly
, temporal hair recession, and an increase in musculature. Serum testosterone level is high.
A recent study has shown that CD56
can be a marker for tumors of this class.
Treatment consists of surgical resection alone with a unilateral salpingo-oophorectomy. The prognosis
is generally good as the tumour tends to grow slowly and usually is benign
: 25% are malignant