Ombos was the first city below Syene at which any remarkable remains of antiquity occur. The Nile, indeed, at this portion of its course, was ill-suited to a dense population in antiquity. It runs between steep and narrow banks of sandstone, and deposits but little of its fertilizing slime upon the dreary and barren shores. There are two temples at Ombos, constructed of the stone obtained from the neighboring quarries of Hadjar-selseleh. The more magnificent of two stands upon the top of a sandy hill, and appears to have been a species of Pantheon, since, according to extant inscriptions, it was dedicated to Aroeres (Apollo) and the other deities of the Ombite nome by the soldiers quartered there. The smaller temple to the northwest was sacred to Isis. Both, indeed, are of an imposing architecture, and still retain the brilliant colors with which their builders adorned them. They are, however, of the Ptolemaic age, with the exception of a doorway of sandstone, built into a wall of brick. This was part of a temple built by Tuthmosis III in honor of the crocodile-headed god Sobek. The monarch is represented on tress, the door-jambs, holding the measuring reed and chisel, the emblems of construction, and in the act of dedicating the temple. The portions of the larger temple present an exception to an almost universal rule in Egyptian architecture. It has no propylon or dromos in front of it, and the portico has an uneven number of columns, in all fifteen, arranged in a triple row. Of these columns thirteen are still erect. As there are two principal entrances, the temple would seem to be two united in one, strengthening the supposition that it was the Pantheon of the Ombite nome. On a cornice above the doorway of one of the adyta is a Greek inscription, recording the erection, or perhaps the restoration of the sekos by Ptolemy VI Philometor and his sister-wife Cleopatra II, 180-145 BC. The hill on which the Ombite temples stand has been considerably excavated at its base by the river, which here strongly inclines to the Arabian bank. The crocodile was held in especial honor by the people of Ombos; and in the adjacent catacombs are occasionally found mummies of the sacred animal. Juvenal, in his 15th satire, has given a lively description of a fight, of which he was an eye-witness, between the Ombitae and the inhabitants of Tentyra, who were hunters of the crocodile. On this occasion the men of Ombos had the worst of it; and one of their number, having stumbled in his flight, was caught and eaten by the Tentyrites. The satirist, however, has represented Ombos as nearer to Tentyra than it actually is, these towns, in fact, being nearly 100 miles from each other. The Roman coins of the Ombite nome exhibit the crocodile and the effigy of the crocodile-headed god Sobek.
In Kom Ombo there is a rare engraved image of Cleopatra VII in the walls of the main temple and also the engraving of what is though to be the first representation of medical instruments for performing surgery, including scalpels, curettes, forceps, dilator, scissors and medicine bottles dating from the days of the Roman Egypt.
At this site there is another Nilometer used to measure the level of the river waters. On the opposite side of the Nile was a suburb of Ombos, called Contra-Ombos.
The city was a bishopric before the Muslim conquest, and Ombos was a titular see of the Roman Catholic Church, Ombi; which has been vacant since 1966. Karol Wojtyła (the future Pope John Paul II) was titular bishop of Ombi from 1958 until 1963, when he was appointed Archbishop of Kraków.