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Benjamin Alman

Benjamin Alman, MD, FRCSC, is the head of the division of Orthopedic surgery at the Hospital for Sick Children in Toronto, Ontario, senior scientist in developmental and stem cell biology at Sick Kids, and vice chair of the department of surgery at the University of Toronto. He has given many speeches and lectures throughout the world, and has won many awards and prizes, including the Premier’s Research Excellence Award, the Huene Award, the OREF Research Award, and the Royal College Medal in Surgery.

Recent Publications

His most recent publications include:

Plasschaert F, Craig C, Bell R, Cole WG, Wunder JS, Alman BA. Eosinophilic granuloma. A different behaviour in children than in adults. J Bone Joint Surg Br. Aug;84(6):870-2, 2002.

Alman BA. A classification for genetic disorders of interest to orthopaedists.Clin Orthop. Aug;(401):17-26, 2002.

Cheon SS, Cheah AY, Turley S, Nadesan P, Poon R, Clevers H, Alman BA. Beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci U S A. May 14;99(10):6973-8, 2002.

Hopyan S, Gokgoz N, Poon R, Gensure RC, Yu C, Cole WG, Bell RS, Juppner H, Andrulis IL, Wunder JS, Alman BA. A mutant PTH/PTHrP type I receptor in enchondromatosis. Nat Genet 2002;30:303-310, 2002.

Meng X, Poon R, Zhang X, Cheah A, Ding Q, Hui CC, Alman BA. Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem. Oct 26;276(43):40113-9., 2001

Tejpar S, Li C, Yu C, Poon R, Denys H, Sciot R, Van Cutsem E, Cassiman JJ, Alman BA. Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour). Br J Cancer. Jul 6;85(1):98-101, 2001.

Li C, Nguyen Q, Cole WG, Alman BA. Potential treatment for clubfeet based on growth factor blockade. J Pediatr Orthop. May-Jun;21(3):372-7, 2001.

Poon R, Smits R, Li C, Jagmohan-Changur S, Kong M, Cheon S, Yu C, Fodde R, Alman BA. Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). Oncogene. Jan 25;20(4):451-60, 2001.

Couture J, Mitri A, Lagace R, Smits R, Berk T, Bouchard HL, Fodde R, Alman BA, Bapat B. A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor. Clin Genet. Mar;57(3):205-12, 2000.

Tejpar S, Nollet F, Li C, Wunder JS, Michils G, dal Cin P, Van Cutsem E, Bapat B, van Roy F, Cassiman JJ, Alman BA. Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor). Oncogene. Nov 11;18(47):6615-20, 1999.

Hopyan S, Gokgoz N, Bell RS, Andrulis IL, Alman BA, Wunder JS. Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. J Orthop Res. Sep;17(5):633-8, 1999.


  1. Dr. Alman's lab
  2. Dr. Alman's staff profile at Sick Kid's Hospital

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