Scalpel blades are usually of hardened and tempered steel. Medical blades are made of high carbon steel, while craft blades can be made of stainless steel; in addition, titanium, ceramic, diamond and even obsidian knives are not unknown. For example, when performing surgery under MRI guidance, metallic blades are unusable (the steel blades would be drawn to the magnets) or may cause image artifacts. Alternatives to scalpels in surgical applications include electrocautery and lasers.
| Blade No. | Compatible Handles | Blade Description | Uses |
|---|---|---|---|
| #10 | 1, 3, 7 | Curved cutting edge with flat back | For cutting skin and muscle in surgery, and for general carving and stencil making |
| #10a | 3, 3L, 3 Graduated, 5B, 7, 9, B3, B3L | This blade is a small and straight | |
| #11 | 1, 3, 7 | Triangular blade with sharp point, flat cutting edge parallel to the handle and flat back | For precision cutting, stripping, sharp angle cuts and also stencil cutting due to its similarity to the X-Acto artknife blade |
| #12a | 3, 7 | A small, pointed, crescent-shaped blade sharpened on the inside edge of the curve | |
| #12b | 3, 7 | A small, pointed, crescent-shaped blade sharpened on both sides of the curve | |
| #15 | 3, 7 | A smaller version of the #10 | For the same general uses as the #10 blade |
| #15c | 3, 7 | The #15 with a downward angle, flatter and thinner than the #15 | |
| #16 | 1, 3 | A narrow chisel-like blade with flat, angled cutting edge, positioned higher than the axis of the handle | For cutting stencils, scoring and etching |
| #17 | 1, 3 | A flat face 1.6 mm chisel blade | For narrow cuts |
| #18 | 2, 5, 6 | A 12.7 mm chisel blade | For deep cuts and scraping |
| #19 | 4 | A similar blade to the #15 | |
| #22 | 2, 4, 5, 6 | A larger version of the #10 | For general use, shaping, whittling and trimming |
| #24 | 2, 5, 6 | A wide, flat, angled cutting edge | For corner cuts, trimming, stripping, and cutting mats and gaskets |
| #25 | 4 | A triangular blade similar to the #11, with the flat back edge taking a downwards angle | |
| #60 | 4 | A long blade resembling the #10 with a long cutting edge, rounded tip and flat back. |
Companies like Jai Surgicals,Bard-Parker and Shippert Medical Technologies offer lines of retractible-blade scalpels which protect users by covering the blade when not in use. Some such scalpels are disposable and others feature replaceable blades on re-usable metal handles.
Graphical and model-making scalpels tend to have round handles, with textured grips (either knurled metal or soft plastic). These are often called by the name of the most well-known manufacturer of graphic arts blades, X-Acto knives. The blade is usually flat and straight, allowing it to be run easily against a straightedge to produce straight cuts.
There are many kinds of graphic arts blades, the most common around the graphic design studio is the #11 blade which is very similar to a #11 surgical blade (q.v.). Other blade shapes are used for wood carving, cutting leather and heavy fabric, etc.
Ancient Egyptians made incisions for embalming with scalpels of sharpened Obsidian, a material that is still sometimes used in modern times.
Indian Ayurveda medicine mentions the use of sharp bamboo splinters.