In general, salicylates, especially aspirin, are used medically to reduce fever and inflammation and to relieve headache, menstrual pain, and pain in nerves, muscles, and joints. Because of the effects of salicylates on blood platelets and clotting, aspirin is often prescribed prophylactically for those at risk of stroke or heart attack. Salicylates are useful, relatively safe drugs, but normal doses can cause gastrointestinal disturbances in sensitive patients and large doses can be toxic or fatal, especially to children.
The effect of sodium salicylate and aspirin on NF-kappaB. (nuclear factor-kappaB; includes reply)(Technical Comment)
Dec 22, 1995; Elizabeth Kopp and Sankar Ghosh find that activation of the transcription factor nuclear factor-[kappa]B (NF-[kappa]B) is...