He succeeded Innocent I, and was followed by Boniface I. Zosimus took a decided part in the protracted dispute in Gaul as to the jurisdiction of the see of Arles over that of Vienne, giving energetic decisions in favour of the former, but without settling the controversy. His fractious temper coloured all the controversies in which he took part, in Gaul, Africa and Italy, including Rome, where at his death the clergy were very much divided.
According to the Liber Pontificalis, Zosimus was a Greek and his father's name was Abram. Some scholars deduce from this that the family was of Jewish origin, but this cannot be certain.
Nothing is known of the life of Zosimus before his elevation to the papal see. His consecration as Bishop of Rome took place on March 18, 417. The festival was attended by Patroclus, Bishop of Arles, who had been raised to that see in place of Bishop Hero, who had been forcibly and unjustly removed by the imperial general Constantine. Patroclus gained the confidence of the new pope at once; as early as 22 March he received a papal letter which conferred upon him the rights of a metropolitan over all the bishops of the Gallic provinces of Viennensis and Narbonensis I and II. In addition he was made a kind of papal vicar for the whole of Gaul; no Gallic ecclesiastic being permitted to journey to Rome without bringing with him a certificate of identity from Patroclus.
In the year 400, Arles had been substituted for Trier as the residence of the chief government official of the civil Diocese of Gaul, the "Prefectus Praetorio Galliarum". Patroclus, who enjoyed the support of the commander Constantine, used this opportunity to procure for himself the position of supremacy above mentioned, by winning over Zosimus to his ideas. The bishops of Vienne, Narbonne and Marseille regarded this elevation of the See of Arles as an infringement of their rights, and raised objections which occasioned several letters from Zosimus. The dispute, however, was not settled until the pontificate of Pope Leo I.
Shortly after this Zosimus became involved in a dispute with the African bishops in regard to the right of appeal to the Roman See clerics who had been condemned by their bishops. When the priest Apiarius of Sicca had been excommunicated by his bishop on account of his crimes, he appealed directly to the pope, without regard to the regular course of appeal in Africa which was exactly prescribed. The pope at once accepted the appeal, and sent legates with letters to Africa to investigate the matter. A wiser course would have been to have first referred Apiarius to the ordinary course of appeal in Africa itself. Zosimus next made the further mistake of basing his action on a reputed canon of the First Council of Nicaea, which was in reality a canon of the Council of Sardica. In the Roman manuscripts the canons of Sardica followed those of Nicaea immediately, without an independent title, while the African manuscripts contained only the genuine canons of Nicaea, so that the canon appealed to by Zosimus was not contained in the African copies of the Nicene canons. Thus a serious disagreement arose over this appeal, which continued after the death of Zosimus.
Besides the writings of the pope already mentioned, there are extant other letters to the bishops of the Byzantine province in Africa, in regard to a deposed bishop, and to the bishops of Gaul and Spain in respect to Priscillianism and ordination to the different grades of the clergy. The Liber Pontificalis attributes to Zosimus a decree on the wearing of the maniple by deacons and on the dedication of Easter candles in the country parishes; also a decree forbidding clerics to visit taverns. Zosimus was buried in the sepulchral Church of St. Laurence in Agro Verano.
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