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Boots, a drug manufacturer from England, was the first company to use Direct-to-Consumer Advertising (DTCA) in 1983 when they advertised Rufen, their own brand of Ibuprofen, on television.

In 1980s, the mind set was against DTCA, however; in the 1990s, many drugs become available as Over-the-counter (OTC), which spurred growth in DTCA.

References By LAWRENCE K. ALTMAN Published: February 23, 1982 40 Years of DTC - from Medical Marketing and Media, Arnold, Matthew.,3915,335%7CRufen,00.html

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