A free thinking man, he was sceptical of religion and disliked the government of the day. He read Thomas Paine's Rights of Man and started to become active in lobbying for political reform. When the Friends of the People were formed by a group of Whigs he joined the Strathaven branch, although he doesn't appear to have been extremely active initially.
However, when it became clear that the local nobleman, the Duke of Hamilton objected to the aims of the Friends of the People many members withdrew and Wilson became more active in trying to maintain the local society.
The Friends of the People eventually folded across the country, but Wilson maintained his radical reformist activities. In the aftermath of the Napoleonic Wars many returning soldiers faced unemployment. In such an environment the scope for radical activity was ripe.
In 1816 some 40,000 people assembled near Glasgow to demand an improvement to their social and political conditions. In 1817 the first edition of the satirical reformist publication, The Black Dwarf was published and Wilson and his radical colleagues would read this at their continued meetings.
Radical activities continued in the West of Scotland around Glasgow, and the government employed a number of spies to interlope the meetings and associations of radical activists. On April 1, 1820 a notice was posted in Glasgow and surrounding areas urging people to rise against the British government, signed by the Organising Committee for a Provisional Government.
This alarmed the government and troops were stationed in Glasgow. Government spies encouraged radicals to rise, telling them that England too was in the throes of radical insurrection. This was a deliberate attempt to cause radical leaders to rise up where they could then be arrested.
Wilson responded in exactly the manner predicted by the government. He led a band of radicals from Strathaven marching towards Glasgow. Wilson was initially wary of the information presented that a rising was taking place (he was informed of the rising by a government agent), and sent a man to visit the rallying point at Cathkin Braes to see if it was true that there was a force of French troops awaiting to assist the radicals.
However, despite there being no French troops in sight, the radicals in Strathaven were keen to march, so Wilson led them towards the city, with the marchers carrying a banner declaring, Scotland Free or a Desert. They marched overnight, and by the next day it was apparent to them by now that there was no mass insurrection. Disappointed and dejected they returned to Strathaven.
However, upon his return Wilson was arrested on a charge of high treason. On July 24, 1820 he was found guilty of treason after facing trial under English law (despite the fact the trial took place in Scotland) and was sentenced to death. He was hanged and beheaded on August 30, 1820.
In 1846 a monument to Wilson was erected in Strathaven.