Part of the body's defenses, consisting of a class of cells widely distributed in the body. Reticuloendothelial cells filter out and destroy bacteria, viruses, and foreign substances and destroy worn-out or abnormal cells and tissues. Precursor cells in bone marrow develop into monocytes (see leukocyte), which are released into the bloodstream. Most enter body tissues, developing into much larger cells called macrophages, with different appearances in various locations. Some roam through the circulation and between cells and can coalesce into a single cell around a foreign object to engulf it. Reticuloendothelial cells also interact with lymphocytes in immune reactions. Cells in the spleen destroy old red blood cells and recycle their hemoglobin; uncontrolled, this process causes anemia. Tumours of the reticuloendothelial system can be localized or widespread throughout the body. Seealso lymphatic system.
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Mononuclear phagocytic system and lymphoreticular system are synonymous with RES.
The reticuloendothelial system is divided into primary and secondary lymphoid organs.
Finally, the spleen filters the blood in search of antigen. Upon the discovery of foreign antigen, all of these tissues react in a similar manner to amass an appropriate and multifaceted immune response.
Lymphoma of the reticuloendothelial system is called reticuloendotheliosis.