The town is a commercial and industrial suburb with shipyards, docks, refineries and foundries. It is known for its rich colonial history, being the home town of Chacón, Guaracheros de Regla and the traditional Virgen de Regla Santería celebrations. It formed during the colonial period around the hermitage of Nuestra Senora de Regla (est. 1690) and was officially founded in 1765. It was a center for smuggling activities during the 19th century.
It is the sister city of Richmond, California.
Regla is divided by Barrios or Colonias such as:
Reparto Modelo, La Colonia, La Loma and La Colina Lenin.