In physiology, reabsorption or tubular reabsorption is the flow of glomerular filtrate from the proximal tubule of the nephron into the peritubular capillaries. This happens as a result of sodium transport from the lumen into the blood by the Na+/K+ ATPase in the basolateral membrane of the epithelial cells. Thus, the glomerular filtrate becomes more concentrated, which is one of the steps in forming urine.Basically, it is getting water into the kidneys. (Water follows sodium). In this way, many useful solutes (primarily glucose and amino acids), salts and water that have passed in the proximal tubule through the Bowman's capsule, return in the circulation. These solutes are reabsorbed isotonically, in that the osmotic potential of the fluid leaving the proximal tubule is the same as that of the initial glomerular filtrate. However, glucose, amino acids, inorganic phosphate, and some other solutes are reabsorbed via secondary active transport through cotransport channels driven by the sodium gradient out of the nephron.
Renin Angiotensin System:
1. The kidneys sense low blood pressure.
2. release renin into the blood.
3. Renin causes production of Angiotensins by the blood.
4. Angiotensins stimulate the adrenal cortex to release Aldosterone.
5. Aldosterone causes kidneys to reabsorb sodium.
6. Water follows sodium.
7. Blood volume goes up.
8. Blood pressure goes up.
An unexpected role for angiotensin II in the link between dietary salt and proximal reabsorption.(Research article)(includes statistical tables)
Apr 01, 2006; We set out to confirm the long-held, but untested, assumption that dietary salt affects proximal reabsorption through...
Absence of significant cellular dilution during ADH-stimulated water reabsorption. (maintenance of cellular homeostasis during antidiuresis)
Feb 27, 1987; Water reabsorption across many "tight" urinary epithelia is driven by large transepithelial osmotic gradients and is...
Cadmium Impairs Albumin Reabsorption by Down-Regulating Megalin and CIC5 Channels in Renal Proximal Tubule Cells
Nov 01, 2010; BACKGROUND: Cadmium (Cd) is a potent nephrotoxicant that impairs the reabsorptive and secretory functions of the renal proximal...