Re-Animated is a live-action/animated television film that aired on Cartoon Network on December 8, 2006. It is a combination of live action and animation. Re-Animated is also Cartoon Network's first original live-action film. The movie features a 12-year old boy named Jimmy Roberts who goes to a theme park named Golly World, where a train runs into him. There, doctors perform an emergency brain transplant, causing Jimmy to see cartoons, more specifically cartoons created by cartoonist Milt Appleday.
With the help of his crush, Robin (Eunice Cho), who is also Craig's sister, Jimmy and the characters learn that the reason they've lost their popularity is thanks to Sonny, who unwittingly ruined their cartoons through his own ideas, especially Golly who is crushed to learn that his top spot as most popular cartoon character in the world has been reduced to nothing, but he figures with Jimmy now at the helm, he can quickly make him a star again. Now that he's president of Appleday Pictures (Sonny was fired by the Chairman of the Board), Jimmy is immensely popular, but no longer has time for school or his friends.
Meanwhile, Sonny has rented out a room in Jimmy's house and now lives with his family because Jimmy's dad allows him when it is obvious that Sonny is deceiving the family. Sonny has dinner with them and meets Jimmy's alien sister, Yancy (Rhea Lando), all the while constantly scheming to get Milt's brain out of Jimmy's head and for himself. And without the brain, Jimmy would die. He devises a plan to modify Crocco's train to include several dangerous devices on it that will decapitate Jimmy and get him what he wants.However, he says this plan out loud (yelling it at the top of his lungs) and Yancy catches on.
Eventually, Robin attempts to point out to Jimmy that the cartoons are walking all over him just like everybody else used to, but he denies this, adding that the only reason Robin even liked him was because of him having Milt's brain. He takes off for his television debut, leaving her behind to encounter Sonny, who says that since she knows his plan, he'll have to do away with her. At the studio, Jimmy tells the ego-maniac Golly that all that the Presidency of Appleday Studios has gotten him isn't what he really wanted, which drives Golly to get angry at him and shout at him that it is impossible for him to say no to anybody. Jimmy finally realizes Robin was right and denounces his position as President, causing the show to be canceled. Sonny, however, still wants the brain, and has tied Robin down to the train tracks, forcing Jimmy and the characters (even Golly who apologizes along the way) to go save her. Golly temporarily changes Jimmy into a cartoon "Knight in shining armor".
Robin is saved from being run over after Jimmy goes inside the train and destroys the engine. Sonny's plan is foiled. Jimmy dresses up as Milt to hide from Sonny, and Sonny is momentarily distracted by his affection for his father. Yancy, Jimmy's alien sister, saves Jimmy just in time by using her power of teleportation. Robin and Jimmy return to Craig's house, where he was planning to throw a party with Jimmy as the guest of honor, and everything is patched up between them. However, since the partygoers were watching the show he was on, and saw him talk about the importance of friendship, they figured that Jimmy wasn't cool, and instead just stupid at giving up all that fame, and leave the party.
In an epilogue, Jimmy is leaving for school. Sonny still wants the brain and is seen hiding behind a curtain. He has a device that can grab his head. Sonny almost succeeds, but the crane misses its target.