In 1931, cartoon character Betty Boop sang a sexy version of the song in the pre-code cartoon Silly Scandal. As Boop sang the song, her dress slipped down repeatedly, revealing a lacy bra and causing her to squeal. Later in the song, Betty was joined on stage by a line of mechanical dancing penguins who stomped out the beat in accompaniment to her singing.
"You're Driving Me Crazy" has become a standard that has been recorded by over 100 artists in many genres. The signature line: "You, you're driving me crazy! What did I do?...." is familiar to most anyone who listened to pop music in the 20th Century. The artists who have recorded the song include many of the greatest artists of the century, including Billie Holiday, Frank Sinatra, Ella Fitzgerald, Louis Armstrong, Sarah Vaughan, Mel Tormé, Betty Carter, Django Reinhardt, Peggy Lee, and Lester Young.
The song has also been performed in the movies including: