See study by L. M. Klauber (2d ed. 1972).
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Timber rattlesnake (Crotalus horridus).
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Rattlesnakes are prey for kingsnakes, roadrunners, pigs,
hawks, and eagles. They have been harvested as human food, such as at the Rattlesnake Round-Up in Sweetwater, Texas.
Different species of rattlesnake vary significantly in size, territory, markings, and temperament. If the rattlesnake is not cornered or imminently threatened, it will usually attempt to flee from encounters with humans, but will not always do so. Bites often occur when humans startle the snake or provoke it. Those bitten while provoking rattlesnakes have usually underestimated the range (roughly two-thirds of its total length) and speed with which a coiled snake can strike (literally faster than the human eye can follow). This can be particularly surprising since the snakes can strike without pulling their body back. This reflex hasn't been recorded in any other species. Heavy boots and long pants reinforced with leather or canvas are recommended for hikers in areas known to harbor rattlesnakes.
Guides are available through booksellers, libraries, and local conservation and wildlife management agencies that aid hikers and campers in identifying rattlesnakes. The advice given is to avoid contact with rattlesnakes by remaining observant and not approaching the animals. Hikers are advised to be particularly careful when negotiating fallen logs or boulders and when near rocky outcroppings and ledges where rattlesnakes may be hiding or sunning themselves. However, snakes will occasionally sun themselves in the middle of a trail, so such areas are not the only places where they are encountered. When encountering a rattlesnake on a trail, you are advised to keep your distance and allow the snake room to retreat.
Rattlesnakes are born with fully functioning fangs capable of injecting venom and can regulate the amount of venom they inject when biting. Generally they deliver a full dose of venom to their prey, but may deliver less venom or none at all when biting defensively. A frightened or injured snake may not exercise such control. Young snakes are to be considered more dangerous, as they have less control over the amount of venom they inject. A young rattlesnake will often simply inject all its venom, which is a deadly amount.
On average, fewer than 15 snakebite deaths are reported. Some rattlesnakes, especially the tropical species, have neurotoxic venom. A bite from these snakes can interfere with the function of the heart, paralyze the lungs, and shut down parts of the nervous system.
The Common Kingsnake (Lampropeltis getula), a constrictor, is famous for being largely immune to the venom of rattlesnakes and other vipers, and therefore rattlesnakes form part of this snake's natural diet in the wild.
Experienced health workers typically gauge envenomation in stages ranging from 0, when there is no evident venom, to 5, when there is a life-threatening amount of venom present. The stages reflect the amount of bruising and swelling around the fang marks and the speed with which that bruising and swelling progresses. In more severe envenomation cases (stage 4 or 5) there may also be proximal symptoms, such as lip-tingling, dizziness, bleeding, vomiting, or shock. Difficulty breathing, paralysis, drooling, and massive haemorrhaging are also common symptoms.
Quick medical attention is critical, and treatment typically requires antivenin/antivenom to block the tissue destruction, nerve effects, and blood-clotting disorders common with rattlesnake venom. Most medical experts recommend keeping the area of the bite below the level of the heart. It is important to keep a snake bite victim calm in order to avoid elevating their heart rate and accelerating the circulation of venom within the body. Untrained individuals should not attempt to make incisions at or around bite sites, or to use tourniquets, as either treatment may be more destructive than the envenomation itself.
Any bite from a rattlesnake should be regarded as a life-threatening medical emergency that requires immediate hospital treatment from trained professionals.
Some jurisdictions outlaw the possession of venomous snakes; where it is legal, some form of license or insurance policy may be required.