Definitions

r.s. shriver jr

Peptide-methionine (R)-S-oxide reductase

In enzymology, a peptide-methionine (R)-S-oxide reductase is an enzyme that catalyzes the chemical reaction

peptide-L-methionine + thioredoxin disulfide + H2O rightleftharpoons peptide-L-methionine (R)-S-oxide + thioredoxin

The 3 substrates of this enzyme are peptide-L-methionine, thioredoxin disulfide, and H2O, whereas its two products are peptide-L-methionine (R)-S-oxide and thioredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming]. Other names in common use include MsrB, methionine sulfoxide reductase (ambiguous), pMSR, methionine S-oxide reductase (ambiguous), selenoprotein R, methionine S-oxide reductase (R-form oxidizing), methionine sulfoxide reductase B, SelR, SelX, PilB, and pRMsr.

References

  • Stadtman ER "Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity". Biochem. Biophys. Res. Commun. 290 62–5.
  • Taylor AB, Benglis DM Jr, Dhandayuthapani S, Hart PJ "Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine". J. Bacteriol. 185 4119–26.
  • Singh VK, Moskovitz J "Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress". Microbiology. 149 2739–47.
  • Boschi-Muller S, Olry A, Antoine M, Branlant G "The enzymology and biochemistry of methionine sulfoxide reductases". Biochim. Biophys. Acta. 1703 231–8.
  • Ezraty B, Aussel L, Barras F "Methionine sulfoxide reductases in prokaryotes". Biochim. Biophys. Acta. 1703 221–9.
  • Weissbach H, Resnick L, Brot N "Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage". Biochim. Biophys. Acta. 1703 203–12.
  • Kauffmann B, Aubry A, Favier F "The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions". Biochim. Biophys. Acta. 1703 249–60.
  • Vougier S, Mary J, Friguet B "Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells". Biochem. J. 373 531–7.
  • Dorsselear A, Branlant G "Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis". J. Biol. Chem. 277 12016–22.
  • Sagher D, Brunell D, Hejtmancik JF, Kantorow M, Brot N, Weissbach H "Thionein can serve as a reducing agent for the methionine sulfoxide reductases". Proc. Natl. Acad. Sci. U. S. A. 103 8656–61.

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