He was commonly named Il Pordenone from having been born in 1483 at Corticelli, a small village near Pordenone in Friuli. He ultimately dropped the name of Licinio, having quarrelled with his brothers, one of whom had wounded him in the hand; he then called himself Regillo, or De Regillo. Others say he once took up his maternal name of Cuticelli His signature runs Antonius Portunaensis, or De Portunaonis. He was knighted as a cavaliere by Charles V.
As a painter, Pordenone was a scholar of Pellegrino da San Daniele, but a leading influence of his style was Giorgione; the popular story that he was a fellow-pupil with Titian under Giovanni Bellini is false. It was claimed that Pordenone's first commission was given him by a grocer in his home town, to try his boast that he could paint a picture as the priest commenced High Mass, and complete it by the time Mass was over; he completed the picture in the required time. The district about Pordenone had been somewhat fertile in capable painters; but Pordenone is the best known, a vigorous chiaroscurist and flesh painter. The 1911 Britannica states that "so far as mere flesh-painting is concerned he was barely inferior to Titian in breadth, pulpiness and tone". The two were rivals for a time, and Licinio would sometimes affect to wear arms while he was painting. He excelled in portraits; he was equally at home in fresco and in oil-color. He executed many works in Pordenone and elsewhere in Friuli, Cremona, and Venice; at one time he settled in Piacenza, where one of his most celebrated church pictures, St. Catherine disputing with the Doctors in Alexandria is located; the figure of St. Paul in connection with this picture is his own portrait.
He was invited by Duke Ercole II of Ferrara to court; here soon afterwards, in 1539, he died, not without suspicion of poison. His later works are comparatively careless and superficial; and generally he is better in male figures than in female-the latter being somewhat too sturdy-and the composition of his subject-pictures is scarcely on a level with their other merits. Pordenone appears to have been a vehement self-asserting man, to which his style as a painter corresponds.