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Protocatechuic acid

Protocatechuic acid (PCA) is an polyphenol antioxidant found in roselle. Data on the biological activity of PCA are contradictory with both anti-tumor and tumor-promoting effects observed in in vitro studies. For example, PCA has been shown to induce apoptosis of human leukemia cells, as well as malignant HSG1 cells taken from human oral cavities. However, PCA enhances tumor promotion in mouse skin cells.


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