Thus, the two substrates of this enzyme are S-adenosyl methionine and protein C-terminal S-farnesyl-L-cysteine, whereas its two products are S-adenosylhomocysteine and protein C-terminal S-farnesyl-L-cysteine methyl ester.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase. Other names in common use include farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, protein C-terminal farnesylcysteine O-methyltransferase, farnesylated protein C-terminal O-methyltransferase, isoprenylated protein methyltransferase, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, prenylcysteine carboxylmethyltransferase [misleading], prenylcysteine carboxymethyltransferase [misleading], and prenylcysteine methyltransferase.
Publication No. WO/2010/018847 Published on Feb. 18, Assigned to Kyowa Hakko Kirin for Recombinant Protein-S Composition (American Inventors)
Feb 19, 2010; GENEVA, Feb. 23 -- Yutaka Kanda, Hiroshi Sato, Tsuyoshi Yamada, Akifumi Kato and Mitsuo Satoh, all from U.S., have developed a...