A $2-billion effort was required to obtain sufficient amounts of the two necessary isotopes, uranium-235 and plutonium-239. At Oak Ridge, Tenn., the desired uranium-235 was separated from the much more abundant uranium-238 by a laborious process called gaseous diffusion. At the Hanford installation (Wash.), huge nuclear reactors were built to transmute nonfissionable uranium-238 into plutonium-239. This method was based on the principle of the self-sustaining nuclear reaction (nuclear pile) that had first been achieved under the leadership of Enrico Fermi at the metallurgical laboratory of the Univ. of Chicago. At the radiation laboratory of the Univ. of California at Berkeley costly efforts were made to separate the two uranium isotopes using cyclotrons, but only about a gram of pure uranium-235 was obtained. The actual design and building of the plutonium and uranium bombs took place at Los Alamos, N.Mex., under the leadership of J. Robert Oppenheimer. Gathered at this desert laboratory was an extraordinary group of American and European-refugee scientists.
The only nuclear test explosion, code-named Trinity, was of a plutonium device; it took place on July 16, 1945, near Alamogordo, N.Mex. The first uranium bomb ("Little Boy") was delivered untested to the army and was dropped on Hiroshima on Aug. 6, 1945, killing at least 70,000 inhabitants. On Aug. 9, 1945, a plutonium bomb virtually identical to the Trinity device was dropped on Nagasaki, killing at least 35,000 inhabitants.
See L. R. Groves, Now It Can Be Told (1962); L. Lamont, Day of Trinity (1965); H. Feis, The Atomic Bomb and the End of World War II (rev. ed. 1966); R. Rhodes, The Making of the Atomic Bomb (1987); R. S. Norris, Racing for the Bomb (2002).
The Human Genome Project involved laboratories in the United States, France, Great Britain, Germany, and Japan. It was financed in the United States by the National Institutes of Health and by the Department of Energy and in Great Britain by the Wellcome Trust of London. A comparable project using new DNA (genetic material) sequencing machines was begun as a private industry venture in the United States in 1998, with a stated goal of completing the mapping of the genome in three years.
Early in 2001 scientists from both teams jointly announced the "completion" of the mapping of the human genome, indicating that they had identified an estimated 30,000 genes (instead of the expected 100,000), constituting just 1% of the total human DNA. Subsequent comparison of the two teams' data has indicated that, because of differences in the genes identified by the teams, there may in fact be as many as 40,000 human genes. A subsequent, more refined estimate (2004) based on additional work on the genome was that there are between 20,000 and 25,000 genes. Work continues on further refining the sequencing of the genes on the chromosomes, eliminating the remaining gaps in the genome map, and identifying the extent of variation in the human genome. In 2007 the first sequences of human individuals (James D. Watson and J. Craig Venter, who led the public and private human genome sequencing efforts, respectively) were released. The NIH's National Center for Biotechnology Information maintains GenBank, a database of publicly available genetic sequences from the genomes of plants and animals, including some extinct species.
See studies by J. Sulston and G. Ferry (2003) and J. Shreeve (2004).
(1942–45) U.S. government research project that produced the first atomic bomb. In 1939 U.S. scientists urged Pres. Franklin D. Roosevelt to establish a program to study the potential military use of fission, and $6,000 was appropriated. By 1942 the project was code-named Manhattan, after the site of Columbia University, where much of the early research was done. Research also was carried out at the University of California and the University of Chicago. In 1943 a laboratory to construct the bomb was established at Los Alamos, N.M., and staffed by scientists headed by J. Robert Oppenheimer. Production also was carried out at Oak Ridge, Tenn., and Hanford, Wash. The first bomb was exploded in a test at Alamogordo air base in southern New Mexico. By its end the project had cost some $2 billion and had involved 125,000 people.
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U.S. research effort initiated in 1990 by the U.S. Department of Energy and the National Institutes of Health to analyze the DNA of human beings. The project, intended to be completed in 15 years, proposed to identify the chromosomal location of every human gene, to determine each gene's precise chemical structure in order to show its function in health and disease, and to determine the precise sequence of nucleotides of the entire set of genes (the genome). Another project was to address the ethical, legal, and social implications of the information obtained. The information gathered will be the basic reference for research in human biology and will provide fundamental insights into the genetic basis of human disease. The new technologies developed in the course of the project will be applicable in numerous biomedical fields. In 2000 the government and the private corporation Celera Genomics jointly announced that the project had been virtually completed, five years ahead of schedule.
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