In media

• Power Play (1978 film), a 1978 thriller film
• Power Play (Angel), the penultimate episode of the series Angel
• Power Play (Star Trek: The Next Generation), a Star Trek: The Next Generation episode
• Power Play (television series), a Canadian television series
• Power Play (album) an album by the Canadian rock group April Wine
• Power Play (quartet), a barbershop quartet

In sports

• Powerplay, a sporting term used in various games
• Powerplay (cricket), a new rule concerning fielding restrictions in one-day international cricket

In video gaming

• PC PowerPlay, a PC games magazine published in Australia
• PowerPlay (technology), a defunct standard for networked video gaming headed by Valve Software and Cisco Systems
• Powerplay Cruiser, a joystick released in the early 1990s

In other fields

• PowerPlay (lottery), a multiplier randomly selected in the US lottery game Powerball
• PowerPlay, a Cognos software product
• ATI PowerPlay, a power managament technology from ATI Technologies