In
enzymology, a
peptide-O-fucosyltransferase is an
enzyme that
catalyzes the
chemical reaction in which an alpha-L-
fucosyl residue is transferred from GDP-beta-L-fucose to the sidechain
oxygen atom of a
serine or
threonine residue in a
protein.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase. Other names in common use include GDP-L-fucose:polypeptide fucosyltransferase, GDP-fucose protein O-fucosyltransferase, and GDP-fucose:polypeptide fucosyltransferase.
References
- Wang Y, Spellman MW "Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells". J. Biol. Chem. 273 8112–8.
- Haltiwanger RS "Modification of epidermal growth factor-like repeats with O-fucose Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase". J. Biol. Chem. 276 40338–45.
- Wang Y, Lee GF, Kelley RF, Spellman MW "Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains". Glycobiology. 6 837–42.
- Peter-Katalinic J "C-mannosylation and O-fucosylation of the thrombospondin type 1 module". J. Biol. Chem. 276 6485–98.
External links
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes