Generalised symptoms include fever, fatigue, weakness, loss of appetite, and weight loss. Muscle and joint aches are common. The skin may show rashes, swelling, ulcers, and lumps.
Nerve involvement may cause sensory changes with numbness, pain, burning, and weakness central nervous system involvement may cause strokes or seizures. Kidney involvement can produce varying degrees of renal failure.
Involvement of the arteries of the heart may cause a heart attack, heart failure, and inflammation of the sac around the heart (pericarditis).
A patient is said to have polyarteritis nodosa if he or she has 3 of the 10 following signs known as the 1990 ACR (American College of Rheumatology) criteria:
It should be underlined that the 1990 ACR criteria were designed for classification purposes only. Nevertheless their good discriminatory performances, indicated by the initial ACR analysis, suggested their potential usefulness for diagnostic purposes also. Subsequent studies did not confirmed their diagnostic utility, demonstrating a significant dependence of their discriminant abilities on the prevalence of the various vasculitides in the analyzed populations. Recently an original study, combining the analysis of more than 100 items used to describe patients characteristics in a large sample of vasculitides with a computer simulation technique designed to test the potential diagnostic utility of the various criteria, proposed a set of eight positively or negatively PAN discriminating items to be used a screening tool for PAN diagnosis in patients suspected of systemic vasculitis.
This disease cannot be currently prevented, but early treatment can prevent some damage and symptoms.
Researchers from Tokyo Women's Medical University, Department of Dermatology discuss findings in polyarteritis nodosa therapy.(Clinical report)
Apr 02, 2010; Research findings, 'Cutaneous polyarteritis nodosa: a report of 16 cases with clinical and histopathological analysis and a...
Recent Findings in Polyarteritis Nodosa Described by Researchers from University of Thessaloniki, Department of Internal Medicine.(Report)
Jan 22, 2011; New research, 'Polyarteritis nodosa in a patient with type 1 autoimmune hepatitis,' is the subject of a report. "Polyarteritis...