• Relative direction, where down is the opposite of up
• Railroad directions, where down and up have locally significant meanings
• Down feather, a soft bird feather frequently used in manufacture of bedding.
• Downland, a type of hill
• Down syndrome, a genetic disorder
• Down (American football), in American/Canadian football, a period of time where one play takes place
• County Down, a county within Northern Ireland

* Down (Northern Ireland Parliament constituency)

* Down (UK Parliament constituency)

• Down (game theory), a standard position in mathematical game theory
• Down (film), an English remake of the film De Lift, about an express elevator that develops a mind of its own
• Down (comics), a comic book published by Top Cow Productions
• Down (novel), a Bernice Summerfield novel by Lawrence Miles
• Down payment, a term used in the context of the purchase of items
• Down quark, an elementary constituent of matter

Music

• Down (band), an American southern heavy metal supergroup
• Down (Sentenced album)
• Down (The Jesus Lizard album)
• "Down" (311 song)
• "Down" (Blink-182 song)
• "Down" (Rakim y Ken-Y song)
• "Down" (Pearl Jam song)
• "Down" (Juelz Santana Song)
• "Down" (Stone Temple Pilots Song)
• "Down" (Chris Brown song)
• Down (Melissa)