Phthalyl amidase

In enzymology, a phthalyl amidase is an enzyme that catalyzes the chemical reaction

a phthalylamide + H2O rightleftharpoons phthalic acid + a substituted amine

Thus, the two substrates of this enzyme are phthalylamide and H2O, whereas its two products are phthalic acid and substituted amine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is phthalyl-amide amidohydrolase.


  • M "Discovery, purification, and properties of o-phthalyl amidase from Xanthobacter agilis". J. Mol. Catal., B Enzym. 2 53–69.
  • Zmijewski MJ "o-Phthalyl amidase in the synthesis of Loracarbef: process development using this novel biocatalyst". Biotechnol. Lett. 18 875–880.
  • Costello C, Kreuzman A, Zmijewski M "Selective deprotection of phthalyl protected proteins". Tetrahedron Lett. 37 7469–7472.
  • Briggs BS, Zmijewski MJ "Enzyme from microbial source: phthalyl amidase". Chem. Abstr. 123 25010.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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