Phenothiazine is the organic compound with the formula S(C6H4)2NH. This yellow tricyclic compound is soluble in acetic acid, benzene, and ether. The compound is related the thiazine-class of heterocyclic compounds. Derivatives of the parent compound find wide use as drugs.
Phenothiazine antipsychotics are classified into three groups that differ with respect to the substituent on nitrogen: the aliphatic compounds (bearing acyclic groups), the "piperidines" (bearing piperidine-derived groups), and the piperazine (bearing piperazine-derived substituents).
|moderate||Chlorpromazine (marketed as Thorazine, Chlor-PZ, Klorazine, Promachlor, Promapar, Sonazine, Chlorprom, Chlor-Promanyl, Largactil)||strong||moderate|
|Promazine (trade name Sparine)||moderate||moderate|
|Triflupromazine (trade names Stelazine, Clinazine, Novaflurazine, Pentazine, Terfluzine, Triflurin, Vesprin)||strong||moderate/strong|
|Levomepromazine in Germany and Methotrimeprazine in America (trade names Nozinan, Levoprome)||extremely strong||low|
|Piperidines||strong||Mesoridazine (trade name Serentil)||strong||weak|
|Thioridazine (trade names Mellaril, Novoridazine, Thioril)||strong||weak|
|Piperazines||weak||Fluphenazine (trade names Prolixin, Permitil, Modecate, Moditen)||weak/moderate||strong|
|Perphenazine (sold as Trilafon, Etrafon, Triavil, Phenazine)||weak/moderate||strong|
|Flupentixol (sold as Depixol, Fluanxol)||moderate||strong|
|Prochlorperazine (trade names Compazine, Stemetil)|
|Trifluoperazine (trade name Stelazine)||moderate||strong|