Saint-Palais-de-Négrignac is a commune in the canton of Montlieu-la-Garde in the Charente-Maritime department in the Poitou-Charentes region in western France.
| Year | Population | Density | Percent of the canton |
|---|---|---|---|
| 1962 | 405 | - | - |
| 1968 | 446 | - | - |
| 1975 | 407 | - | - |
| 1982 | 388 | - | - |
| 1990 | 351 | - | - |
| 1999 | 329 | 17/km² | 5.34% |