In 1807, he began studies at the Petit Séminaire de Montréal, where remained until 1812 after which he was employed at a prominent hardware store owned by Arthur Webster. After nearly a decade there, Fabre spent a year in Paris to gain experience in book retailing at the Galeries Bossange.
Fabre remained in the bookselling business for years while supporting the Patriote movement for much of this time.
In 1848, Fabre entered municipal politics when he was elected a councillor in Montreal's East Ward. The following year he was elected Mayor, prompted financially restructuring of the city's finances and introduced measures to manage a cholera outbreak. Despite his reluctance to serve a second year as Mayor, Fabre served in that role until 1851.
Édouard-Raymond Fabre contracted cholera and died July 1854. Leading politician Louis-Joseph Papineau paid tribute, delcaring that Fabre "rendered outstanding services to the country.”